The first mule deer I shot was back in 1953 with a Mdl 70 270 Win rifle, The last one was in the 2005 season with a .264 Win Mdl 70 Win rifle. Between those years I have shot deer with 22-250 Rem, 243 Win , 257 Roberts, 25-06 Rem, and 308 Norma Mag rifles. Most of them were with one shot. If my old body will let me I may take out a Win 94 30 WCF Saddle Ring carbine Mfg 1932 but have the 264 Win as backup.