Hmmm...I am a fan of the .45LC. A 4" S&W M-25 is one of my favorite revolvers.
But I recently "re-discovered" the .44Spl after about ten year's absence. I re-acquired a 5-shot Taurus (yeah, I know) M-441 3" blued revolver that is about the size and weight of a K-frame.
Really a carry-able, shoot-able revolver, and though I'd rather
have six rounds of .45LC, I'd rather
carry the smaller, lighter M-441. I swap back and forth between the two, but as my wrists and everything else age, I see the .44Spl becoming more appealing.
A few years ago, I went through the same exercise with .45LC and .41Mag, and ended up selling the .41. I don't necessarily foresee abandoning .45LC any time soon, but in the fullness of time, anything is possible.
Note: I handload for every centerfire firearm I own, so no conflicts regarding ammo cost or supply.
Edited to add...Kevin: you have an amazing collection.