They are here to stay. Just like wild hogs in the southern states, Asian carp in the Mississippi River, these non-native species are too dug in and will never be eliminated via the current efforts in place.
Having handled, been bitten by, and raised pythons and other snakes in years past, I will echo Art's description. They are nothing like rattlesnakes. They are slow, even when striking. I was able to dodge a number of strikes from pythons just by reading their body language and being quicker than they are. And they are easy to kill. I'd probably go with a decent 28" machete for any snake that I can get in on quicker than she can escape, but the ones that start to run would get the shot shell. Snake is not bad eating IMO.