A 220 softnose is a tremendous bullet in the '06, with nearly unbelievable terminal effect. They are out of fashion these days because they are not good for imaginary 800 yard shots.
A cast 220 is good for practice, for the handful of hunters who both use a 220 SP, and who actually practice.
They don't, however, hit anywhere near the same place as 110s.
It is certainly possible that a particular gun won't shoot them well, but the shooter wouldn't know until he actually got them on paper - and sighting-in at 25 yards is a fine way to avoid wasting powder and bullets.