Ive always carried a full size handgun, as well as a double reload, and more often than not, a BUG. Ive done that 18/7/365 most of my adult life.
Started out back in the mid 70's with Colt GM's and Commanders (as well as a short stint with a couple of High Powers), and a PPK or SIG P230 as a BUG, sometimes a J frame of some sort instead. Usually a double reload for the .45's. Did that daily for about 25 years.
Switched over to SIG's back around 99/00, P220's, 226's and 229's mostly, before finally settling on the P226, usually along with a double reload and a P230.
Since around 07, its been a Glock 17, double reload, and a 26 as its back up.
Carrying a full size gun isnt hard, but it does take some dedication. Once you get used to it, its no big deal, and you only really notice it, when its "not" there.
Im really amazed sometimes when I hear people say they couldnt possibly carry anything bigger than a Baby Browning, or one of the current "little" guns. Personally, I think its all about "want", than it is about "cant".
Hey, to each his own. We all have to deal with it the best we can, and live with our choices.