I used to believe that big bore bullets, at Magnum velocity, would be a best choice for antipersonnel purposes. Nothing wrong with big bores, and nothing wrong with high velocity, but one can overdo it.
Unfortunately, I did not fully understand the importance of an ergonomically-proper grip, to the long-term health of one’s hands, so, I fired too many .44 Mag rounds, through my rookie-year duty revolver, an N-Frame S&W Model 629, with K/L-Frame-sized hands. I have deep palms, so like the feel of an N-Frame grip, but my fingers are medium-length, and my thumbs are relatively short. To get enough finger on the trigger, for a DA pull, I have to hold an N-Frame with what some trainers now call an “h” grip. That sends more of the recoil force through the thumb, and violently torques the wrist, very unnaturally, with each shot.
At the conclusion of my rookie year, I became eligible to qual with an autoloading duty pistol, and, largely because my hand needed to heal, I carried a 9mm duty pistol, for about six or seven months. I then resumed carrying a big-bore Magnum revolvers, though a Model 58 .41 Magnum, which, notably, has a narrower trigger than the wide triggers typical of most N-Frames. This allowed a better grip, ergonomically, on the weapon, so, I was doing less damage, per shot, than with the 629, but it was still an imperfect grip, and each shot was causing cumulative damage. Relief did not come until 1990, when I transitioned to a Colt Commander duty pistol, and started using Ruger GP100 and K-Frame revolvers.
I sold that 629 to a colleague. I still have the Model 58, but its parts are too loose for me to want to shoot it, anymore. I may eventually buy another N-Frame, but I will only shoot it single-action, so I can use a proper, ergonomic hold, while being able to reach the trigger.