I don't get all wrapped up around the axle when choosing a dedicated defensive pistol. Doesn't matter whether it's carried on my hip or available for use when I'm at home. It's a handgun.
The mindset, skillset, knowledge of practiced tactics & the relevant laws and the experience of the user of the firearm, being employed as a dedicated defensive weapon, are probably of greater concern than the specific choice of equipment.
So ... which one would you select, and how well can you safely, accurately and effectively use it ... especially in an unexpected dynamic, chaotic, rapidly evolving deadly force situation, occurring in a confined area, and probably occurring under reduced/dim light conditions and where family members may be at risk?