I have a Colt 2nd generation 1851 Navy, a reproduction Remington .36 and a reproduction Colt 1862 Pocket Pistol in .36 caliber.
I've never shot anyone with any of them, and hope I never do.
However, I regularly shoot into a large cardboard box with alternating layers of 1/4-inch plywood and hard-packed newspaper.
The .380 diameter soft lead ball often flattens out to about the size of a dime, some flatten to the size of a nickel.
With 24 grs. of Goex FFFG muzzle velocity is about 1,000 feet per second. At that speed, that soft lead ball has a tendency to flatten.
Remember, we're talking about a very soft lead ball. And don't forget, that when it is rammed into the chamber it is no longer a sphere. Its shape is best described as half an orange placed on half a grapefruit, meat-to-meat. This creates a slight shoulder, the precursor of the later semi-wadcutter bullet design.
The late gun writer Elmer Keith (1898 - 1983) grew up around Civil War vets, in Montana. He started packing a Colt 1851 Navy in 1912, when he was 14.
In his book "Sixguns," Keith quotes one veteran as saying that the round ball from a .36 Navy took all the fight out of a man, whereas the conical bullet didn't (even though it was heavier).
I don't know if Hickock carried the lead ball or conical bullet in his Navy Colts. I suspect the ball, since he was quite familiar with their proper use.
I must respectfully take issue with the idea that infection killed most of the soldiers in the Civil War. Infection takes a while.
I believe that shock, loss of blood, pain and terror probably combined to take their toll.
Yes, opiates were available but they weren't available all the time. It would have been easy for a doctor to run out of them, given the masses of wounded. And remote areas such as Army forts and mining towns would have had a limited supply. Some of these places didn't even have doctors.
The lack of modern diagnostic equipment undoubtedly caused many deaths. The first X-Ray machine didn't come along until the end of the 19th century.
Often, to find the bullet, the surgeon inserted a long, thin rod into the bullet channel. This would often worsen the injury by pushing the bullet farther, or lacerating blood vessels. Add to this a patient writhing in agony and you can see where shock and bleeding would be quickly fatal.
Whenever someone laments that they were born too late, and tells me they want to live as the Cowboys, Mountain Men or Indians did ... I usually reply, "Go spend a winter in a tipi in North Dakota, with an abcessed tooth, then tell me how much you hate the 21st century."
Thank God for modern medicine and such!