What Majic and Ben are saying , if I may be so bold as to speak for them here, is keep a CLOSE eye on the chrono. When your charge increases you get a velocity increase, for the sake of simplicity let's say you get 20 additional FPS for every .2 grains increase from a mid-level load and it is more or less consistent all the way up near the top load. You load up .2 grains more and you only get 10 FPS, kinda strange but no pressure signs that are scary, so you load up .2 more on top of the last load that only showed a 10 fps gain and get another abnormal gain or very little gain. This is your key that you better stop and stop now. When a normal gain is not seen it is telling you the reaction of the powder to the situation in the case at firing is not normal and that you cannot assume the reaction of any changes to the load will be normal. It could be that nothing will happen with another increase or it might be that you will be having your hand sewn back on, you just don't know until you try it. Some powders will actually start lowering velocities with further increases and some will blow your gun up. The key is to know when to stop and 'mapping' your loads with the chrony is the only scientific and somewhat valid way of working loads up without pressure testing equipment.
Granted this is a very simplistic flyby from high altitude but I hope it helps.