I personnaly don't shoot bullets that light in my .22-250, but I did help a friend work up a load for his Savage M12 HB.
We started with 38.0gr of Varget (his choice of powder, not mine) and worked up to 41.0gr (book max). We were getting around 4,200fps and under MOA accuracy (near 1/2moa) with a 40gr Nosler Ballistic Tip. He later substituted the 40gr V-max with similar results.
However, the epilog to this story is the important part. He took that load and rifle to Colorado for a p-dog hunt. Got into the dogs good, and got excited and shot up all of his 300rds of ammo in single sitting. The next day, he bought some Win. White Box 45gr factory and shot another 100rds...
But, he noted towards end of first day shoot he was missing more than hitting. After he got back and had cleaned the rifle well, he took it to the range. Low, and behold, his rifle wouldn't shoot under 4moa no matter what he did. I took one look at his bore and showed him how the first 3" of the rifling in his barrel was gone!!! He had burnt out the barrel in one sitting....
He sent rifle back to Savage and they rebarreled it under warranty, with the admonition to "slow down" on shooting the rifle. And, they wouldn't replace the barrel again.
He's switched to a 50gr bullet, and also takes a Bushmaster AR15 Varminter when he goes to take the "heat" off the Savage.....
Past 300yds, the 50gr bullet shoots flatter and exhibits less wind drift......
I use 55-60gr bullets in my Rem. M700ADL (thin barrel). It shoots 55 and 63gr Sierra's over 39.0/38.0gr of H380 into 5shot-1hole groups. I don't shoot it excessivly as I want it to keep doing that....