Guns are one thing that does not fit the assumptions of size.
Clearly women are fully capable of using most firearms. There is some exceptions of really high recoil or heavy items that would benefit from additional strength and be too much for many men and most women.
That said we know what is meant by the "girls gun" comment. It is to imply the firearm is smaller, and by conclusion weaker and more suitable for a girl.
Unfortunately this is even a mistake some women make picking out a firearm for themselves the first time. One you have to politely point out to a new shooter so they won't be intimidated when they touch off thier first shots in some tiny little cannon and dislike shooting from then on or develop a flinch.
Smaller guns weigh less, have shorter barrels, and as a result both kick more and have more muzzle climb in a given caliber than a larger firearm in the same caliber.
So a "girls gun" or a lower recoil more manageable gun as implied by the term would actualy be a larger gun.
A small airweight snubnose would be less appropriate for someone more recoil sensitive than a full size revolver in the same caliber.
It takes more strength to accurately shoot a lightweight snubnose rapidly than a larger full size gun.
Society and Hollywood will continue to think bigger is more powerful and harder to tame however. So a big heavy gun with little recoil is macho and masculine, while the hard kicking little snubby is weak and feminine.
The truth is a 9x19 full size semi-autopistol firing a more powerful cartridge kicks less than many lightweight .38 Special snubnose revolvers.
Or comparing revolvers to revolvers a .357 Ruger Redhawk considerably overbuilt in that cartridge looks like a big "manly" gun, but would be far easier to shoot than your average small CCW .357 Magnum, or "girl gun".
Both men and women will find larger heavier pistols easier to manage.
In fact heavier pistols are so much easier to manage some states even have laws that classify pistols weighing more than X number of ounces "assault weapons". Thier extremely easy to manage recoil and hence faster accurate follow-up shots making them a greater percieved danger, and a greater target of gun grabbers.
For example in the Federal "Assault Weapon" Ban pistols weighing more than 50 ounces, or about 3 pounds unloaded were "assault weapons".
Some states continue to have arbitrary maximum weights for handguns before they become "assault weapons".
Some restrictions are really extreme. Take this one once proposed in Iowa
http://www.legis.state.ia.us/GA/76GA/Legislation/HF/00200/HF00234/ :
20 ounces are more would have become an assault weapon, or 1 pound 4 ounces.
So in conclusion a lighter smaller gun is most certainly not an easier gun to control in a given caliber. Or a "girl gun" by those using the term to imply that. A massive heavy chunk of metal would be the easiest to tame. Only someone ignorant to firearms and the laws of physics would think otherwise, which seems to be most of Hollywood. Hollywood after all only fires blanks with almost no recoil, or uses special effects in most movies. Nobody is actualy firing a payload generating recoil, so it is easy to remain ignorant even working with thousands of firearms.