I find it interesting to see such a strong representation of the venerable .44 Magnum cartridge. Several years ago this would've been my immediate choice, as well. It can do just about anything someone would reasonably require that a handgun be able to do, and then it can be loaded to address tasks which are beyond the performance envelopes of less powerful handguns.
The reason I wouldn't select it as my first choice any longer ... but which doesn't at all diminish my respect for those that have selected it for this thread ... is that I've experienced more wear & tear, with more frequency, on my various .44 revolvers than with my "less powerful" caliber pistols & revolvers. Quite simply, even my later "improved" S&W 629-4 Classic, Ruger Super Blackhawk & my Ruger Redhawk have required more "adjustments" and maintenance than my smaller caliber defensive pistols have ever required.
Okay, maybe they might do better if I restricted my ammunition to standard factory magnum and special loads, but I grew up being told that .44 Magnums were "intended" to be shot with Elmer Keith's favorite magnum load.
Fortunately, one of the other armorers is a revolver armorer, so it's not an issue whenever one of them needs some minor adjustment after a lot of heavy factory loads and handloads ...
But what if those services weren't easily available any longer? I've become of the opinion that it's easier to keep a service pistol running trouble free for longer than a service revolver ... and it's rapidly becoming more common to encounter folks that shoot a LOT more than we used to ...
I've got many thousands of rounds through some pistols, and I also have a couple of friends that have easily exceeded 20,000 & 25,000 rounds through their personally owned 9mm's, .40 S&W and .45 ACP pistols. I'm not sure my .44 Magnum revolvers would give me the same level of endurance ... but there are more and more pistols that will. Sigh ...
Besides, while I carried a couple of my .44 revolvers for off duty weapons for several years, I eventually grew tired of carrying the extra weight around.
My answer may change when I retire in another couple of years and move somewhere farther out in the country, though ... I always did like the balance and "feel" of my 4 5/8" Blackhawks.