Depends on what you are shooting. For shooting people, round ball and 30 grains is fine. Some would say a round ball loaded heavy will smack a man down faster than a slug. I think there is truth to that, but hard to find volunteers for a study.
But...if one is shooting at a pack of wolves closing in, or an aggressive cougar, I'd want lots of 4fg under that ball, no fillers or corn meal, and reasonable to excellent accuracy at 25 yards. Aggressive black bear, I'd want a slug over a full charge, no corn meal. !!!! For those threats, the pistol must shoot to POA, as those animals are short wide targets, not long and skinny like a people (well, most people...some people?) and no belt buckle to aim at.
Depends on what the threat is.