I can't fault the 10mm-ites talking up their favorite cartridge, because in some ways it makes sense. But what gets me about the 10mm is that it requires a larger gun, a heavier gun and it really doesn't accomplish anything the .40 or .45 can't. You can load a 10mm hot and heavy, but you can load any cartridge hot and heavy (compared to factory stuff) for that matter.
Well, if we're comparing apples to apples, ... at least when choosing among the usual so-called "service cartridges" and the platform of an easy-to-pack autoloader (i.e., 9mm, .357Sig, .40S&W, 10mm or .45acp), it's not even close.
A 15+1 G20 (or 10+1 G29 for that matter) won't be
that much weightier than another caliber of Glock (or, e.g., an M&P) when similarly loaded to max magazine capacity, e.g., a 15+1 .40 G22. But the 10mm Glock's payload will easily pack the most punch on delivery, if properly loaded for the task. The key on the G20's portability will be the mode in which its user chooses to carry it. The right belt/holster combo will make all the difference.
As far as "other cartridges" being loaded "hot & heavy," that's when these trail-gun discussions usually migrate into comparing something like a G20 to a magnum revolver. While the magnum wheelie advocates talk a good game, when you're actually out on the trail these guns quickly become 6-shot boat anchors and wind up being dumped into the bottom of the backpack where they're about as useful, when needed, as if they'd been left back at the cabin or camp site.
By the way, more and more trail guides and pilots in Alaska are packing an autoloader rather than a magnum revolver, and guess what? It's not a "Glock Fortay" ...
It's a 10mm G20, loaded up with one of the "hot-n-heavy" factory loads from DT, BB, Underwood, or the user's own hammerhead handload.