Cylinder stop notch placement could also be significant as that is the weakest point and most prone to fail. 5 shots puts the notches between chambers rather than directly on them. I've always been under the impression this is a significant consideration in the design, but I'm not an engineer or designer...………..
I would definitely be interested in this with a 5 inch barrel, but in a GP100 perhaps or if Colt (really unlikely) ever jammed it in the new python frame. I'm not liking or trusting Smith's lately.
I'd likely go with low level 41 magnum power levels. There's nothing that lives near me that they wouldn't be adequate for in a SD situation.
If hunting I'd go with an N frame or Redhawk framed gun, scope, and hot loads. But if I'm stepping up to a Redhawk frame size with the intent to hunt, I'd go 44 mag in a Super Redhawk. Guess what I'm saying is a 41 in an L frame would be a SD gun only for me.