Shoot, I might as well jump in here too.
Not sure what is meant by a full size .357, a Highway Patrol, mod. 27???? those are full size. For years I carried a S&W mod. 19 & it was comfortable. Remember what Clint Smith said. A handgun should be comforting not comfortable.
Even the big guns can be carried comfortably with proper leather, yes I said leather. Simply Rugged makes exellent holsters that will allow you to carry a gun relatively comfortable all day.
www.simplyrugged.com I'm not affiliated in any way except using them.
My pick for today would be the S&W mod. 19, 66, 13, 65, the Ruger Speed & Police six. I would stay away from those with underlugs unless you went to the Python (it's actually the old Colt .41 frame) underlugs add weight & really serve no useful purpose (I expect to be disagreed with here) but I still feel I'm correct. At least for me. If I'm going for more weight, I'll add a bigger frame & caliber!
I'd probably want a smaller gun for summer where usually only a shirt is worn, though if you wear a shirt untucked, a larger gun can be carried without detection.
Remember you can use .38 Special target loads for 99% of your practice & small game hunting. It's really fun to shoot in a .357.
Good luck in your search.
Frank