Bullet weight can influence penetration, as can design.
The "best" bullet for SD against people may not be 1st pick for a bear.
For people, look for a bullet that expands and penetrates 12-18'' of gel after "heavy clothing" (Regardless of caliber)
In 10mm Hornady Critical Duty 175 gr. performs well, 13'' penetration expanding to .69
In before anyone makes generic comment about 10mm over penetrating, not true as seen above.
In before generic comment about 10mm being too powerful for SD, not true some loads have recoil on par with 45 acp.
In before generic comment about 10mm either being watered down 40 or too hot for SD, as if nothing reasonable (in-between) exists.