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These are my thoughts, they are extensive and they are irrational. If you choose to read them, you do so at your own risk, realizing that I may be wrong or that you may not agree with me. I use over-exageration to illustrate simple points and nothing can be taken literally that I have written here. That said, enjoy!
"I have no professional training". Famous last words aside, I don't see the other side of this debate as in close-quarters use of a firearm. If a person is within my arms reach, I am going to revert to tackling, grappling, pushing into walls. In other words, in cqc I will revert to cqc methods. I will not stop, reach for my pistol, pull it out of its deep concealment and attempt to take aim WHILE women and children are on all sides of me as some in this thread have suggested.
Going back to the basic principles of self-defense, your primary goal is never allowing someone the opportunity to attack you. Don't walk down a street at night alone, don't sleep with your doors unlocked, don't walk in to a bar and start mouthing off, etc. If you take all defensive measures necessary you'll likely never need to attack anyone and that is, in essence, the nature of a firearm... and OFFENSIVE weapon.
If you can accept my premise, which is that a gun is for killing. I don't see how a .22 is incapable of being used as an OFFENSE. I have carried a knife now for over a year, and I believe that it is and adequate OFFENSIVE WEAPON (as if there were any other type of weapon) but I take issue with it and its ability to be turned around on my person in a cqc situation. A .22 has at least the same devastation capabilities as a knife blade (understatement) with the added ability of being able to be used from up to 20+ feet away, and god willing, to be able to strike multiple times.
In other words, there is only one situation in which I would use a firearm for self-defense, or more appropriately on the offensive, and that is if a person 1) has a bat, crowbar or machete or something else that I am unable to defend against with conventional hand-to-hand methods AND 2) fleeing is not an option.
No, a .22 can't STOP a person dead in their tracks. The same can be said for a .38 but S&W j-frames continue to increase in popularity by the day. The same is true for 9mm with standard ammunition but people carry those every day and sleep soundly at night. Sure you can carry a .45 or a .50 "hand-cannon". Hell, if you can fit one of those on you, you're not in a gun-sensitive environment so why not just get a SBS and pack it with slugs. If you're going that far, you're probably wearing a trench coat, so you might as well get a fully-auto AK-47 with a folding stock... if you can carry whatever you want then you're not living in the city... so just get 30-06 and "just wait".
As your rounds get bigger your over-penetration likelihood increases. At a certain point, it is guaranteed. Beyond that, you can start lining people up if you wish. A comprehensive answer is simple: if a .22 is all you can carry because anything bigger will leave a big, fat "I'M ARMED" stamp on you then you don't need to hear any more about how it is simply not adequate, or how it is simply going to work... yes, we get it, purists, unless you're firing a mini gun from an apache attack helicopter into a group of enemies you're not doing enough damage.
To close my thoughts, I have to say that I have a fundamental disagreement with the term "stopping power". A 10-pound sledge hammer has "stopping power". A navy battleship's cannons have "stopping power". A train has "stopping" and indeed "going the other way" power.
My version of the question is simply this, "can a .22 severely injure a person and, indeed, kill a person?" The answer? Yes, and so can a bic pen. But I can't throw ten bic pens at hundreds of feet per second, can I?