Again, the beauty of really powerful rounds is that a light-for-caliber expanding round going really fast typically penetrates less than a slower, heavier round, while simultaneously being more effective. This is why a carefully selected rifle round is the best home defense cartridge: stops the threat decisively while being less of a danger to anyone you didn't just deliberately shoot.
For example, after trying out some .223 Federal American Eagle 50 grain JHP, I found that these rounds had extremely violent expansion but considerably less penetration than 9x19mm defensive loads.
John