To continue with others here, there are (IMHO) two separate tiers of .380: what I call "full size" (which are still pretty small) and "micro" (as small as can be reasonably expected).
The obvious arguments against the first tier (also as above) are twofold: #1) there are now 9mms and 40s that are in the same size range and #2) a lot of them are straight blowback–which means that felt recoil can be stiffer than one would think. For example, the PPK in .380, to me, feels snappier than my alloy frame compact 9mms, as does my all-steel bersa 383.
Still, the guns can be pretty great, as mentioned above: Beretta 84/85/86, Browning's BDA version, Cz-83, Sig 232 (in both steel and alloy), PP/PPk and even the Bersa (I have two bersas, an old Beretta '34 and a PPK).
The second tier is hard to argue with, unless one just refuses to abide with the .380. These strike me as pretty usefull and this opinion is backed up by a lot here, to say nothing of sales figures. Exemplars include the above kel-tecs, the LCP, the sig P238, the Kahr P380, the micro eagle, the NAA guardian, the seecamp and a few that I'm forgetting.
I've been on a research tear of late, and based on owning a couple of, ahem, "full-size" blowbacks, and having shot the LCP and Kahr, I've boiled it down to either the Kahr or the Sig 238 for me; just about neck-and-neck. I'm told by folks that have shot both that the sig is the better handler. My only reservation on that is the condition-1 carry for your purse; that said, I'd give one a look.
The kahr, kel-tec/LCP and sig are all smaller in terms of height/length than the PT-22 (I've got one, as does my lady), FWIW
At this point, I'm leaning towards the kahr, but only because it is absolutely the lowest-profile of them all (not by very much though) and I like the way it shoots. I feel that it is a hair less snappy than the LCP, again, FWIW. Certainly no worse than my alloy Bersa, though the Bersa has a lot more to hold onto. I'd bet the Kahr would be a pussycat with the grip extension now available (maybe someone here knows for sure; the LCP owners seem to like their pearces...).
For your pleasure:
http://www.kahr.com/PA-1B/review_ah091009.html
http://www.tngunowners.com/forums/handguns/26885-four-380-s-compared-images.html
http://www.glocktalk.com/forums/showthread.php?t=1119974