The 3-screws I've handled have the same balance, weight and grip size as the New Models (2-screws).
The feel of the action is different, but I find added value in the transfer bar, personally. Depends what you want it for.
The 50th Anniversary has the New Vaquero grip frame, similar to the Colt SAA and 1851 Navy cap-n-ball. Shorter LOP, smaller all around, only fits one hand.
Handling and balance would be quite different from the other Blackhawks, including 3-screw versions, with larger grip frames.
Which one do you like? Depends on which one you like.
There's a 3-screw at a store down the road with a worn finish for $300. It's been there for a good while without any takers. If you want a 3-screw, buy one. They may be collectible, but they can still be had for a reasonable price.