I will come out of the closet and admit that I own a P250. While I cannot necessarily recommend it due to the documented issues experienced with the gun, I have not found any major issue with mine so far.
The gun appears to run reliably using a variety of FMJ and JHP ammo. I have not had a single stoppage yet, though granted I have not run the gun very hard yet either.
The ergonomics are solid IMHO, and the ability to rapidly convert calibers is neat now the SIG is FINALLY getting the kits out on the market. The gun seems pretty well-built, although the polymer components feel a bit cheap. The gun also seems reasonably accurate (though I am honestly not good enough a shooter to push a pistol to its maximum accuracy).
The major beef with the weapon seems to be the trigger. I'll just come out and say that I have no huge beef with it. In fact, compared to a typical DAO trigger, I don't really mind it much. It is considerably lighter than other DAO triggers I've tried as well as some striker-fired triggers. The long reset is the only issue but can be overcome with practice.
If I have time this weekend, I plan to grab a bunch of 9mm and replicate the ATF's test (2x 50 round shooting sets, 1x 100 round shooting set) to see how it does. I obviously don't have time/$$$ to shoot 20,000 rounds in one day but running a few hundred rounds at once ought to give a pretty good impression.