Speaking from FITST HAND range time with the 500 magnum:
* NO it wont break your wrist. Any medium framed male can handle the recoil with a 2 handed grip. Im only average, and had never shot anyhting larger than a 357 before i shot the 500. My wrists were not broken, The gun didnt go flying, it didnt jump back and hit me on the head. It kicks very hard, but its not uncontrollable.
* NO It wont blind you, but there is a good sized muzzle flash, even with the long barrel.
* NO it wont break your ear drums. I shot the 500 indoors, and standard ear muffs were enough to keep my ears safe. No ringing.
* YES it is very heavy.
* YES the trigger and Hi-Viz sights are good. It is plenty accurate for hunting applications. THAT being said, its not going to give you rifle-tight groups; you have all seen pics of this thing with a scope and a bi-pod. Have NO delusion, this gun is not a snipers weapon.
I do NOT think this handun is combat worthy. It is simply TOO big, TOO loud, TOO heavy, TOO slow, and low capacity ta' boot. Its big and heavy enought o be awkward in CQB efectively negating the pistols only advantage. It also takes a few SECONDS to get back on target with full power loads.
The answer is NO.