If only it were that easy to choose what animal you are around. Odds are if you are in bear country, you are in wolf country. If anything mountain lion are the most unnerving to me.
That's true, but one has to consider the locality. There have been numerous issues with wolves in Montana and Wyoming. In that location brown bears are more commonly called grizzlies, because they represent a subspecies of brown bear that are known to be smaller than Alaskan bears, and certainly coastal browns, and happen to have a grizzled appearance. They are all brown bears though. Given the smaller stature of the grizzlies and high wolf population, I would happily carry a 10mm as there is just a better chance of it covering both bases. I've been accidentally entirely too close to a grizzly before, and am confident in that assertion. Moose, I question that one, but you specifically mentioned the cohabitation of bear and wolves, so we can put that aside.
One also has to consider the behavior of wolves versus bear. Wolves are persistent and dogged hunters, but are easier to scare off with loud bangs, and once one or two of their pack goes down, survival mode kicks in. If you don't see them coming, well it may be moot. Brown bear on the other hand have a little different response and behavior. If you startle them, they will run, or attack. If they attack, they can get pretty revved up, and adrenaline takes over. I've seen videos of charging bear that have already been shot and keep coming. Given the larger dimensions of inland and coastal Alaskan brown bear, a smaller slug has less chance of hitting vitals or breaking bone on an animal that may outweigh it's lower 48 brethren by 400 lbs., depending where you are. My point is that Alaskan bears are a lot different brown bear than inland grizzly. Kodiaks are an entirely different scenario, and far scarier. The record was over 1500 lbs.
If I'm potentially going to be faced by an animal that could range from 600-1000+ pounds, depending on the location in Alaska, that can sprint at over 30 mph, and I'm only likely to get off one or two aimed shots, then personally, I want a cartridge with more bullet mass than a 10mm can offer. Talk to big game hunters and see what they say about large bodied dangerous game. The OP also mentioned he would be carrying a 375 H&H. That is wise, and a far better option for bear and moose than any handgun, and as far as I'm concerned, gives him adequate capacity without a 15 round Glock 20.
It's just my opinion, and no one is obliged to agree. And of course all of this opinion is rendered irrelevant if a person shoots a 10mm better than a 44.
Regarding cats, I go for one or two short hikes after work each week. It looks like this where I live.
View media item 2426View media item 2425
The other day I walked out, and hit my turn around spot and passed back over the same ground about 10 minutes later. This is what I found.
View media item 2423View media item 2424
I literally missed this lion crossing my path by ten minutes. Those are my tracks on the far right. They are in a lot of places, but there are so few lion attacks on people, and they are no harder to kill than a human, that I am content carrying a 9mm, 357, or 10mm where I live.
About 4 weeks ago one of my employees found an intact lion that was about 4-5 years old and frozen in the snow. It weighed in at 120 lbs. He got the skull back.
Cats are all over the place, and sneaky. I've seen two, and one was moving so fast all I could think was "Wow, a gun would've made no difference if it was attacking me." At the same time, a Colorado man choked one out that attacked him just a few weeks ago. Young males do dumb things. So the bottom line is keep your eyes and ears open, look over your shoulder now and then, and you'll probably be just fine.