Glock 19 with night sights in a fanny pack nearby. In the fanny pack is an extra mag, a Surefire M2, and if I need it, I can toss my cel phone in there while checking out the noise in the middle of the night.
Yes, I agree fanny packs are about useless for normal carry, but this works for me since I sleep in boxers and a T-shirt. Holstered gun + boxers = not so fun times. My old nightstand gun was a P226 and I had a shoulder holster for it, but I couldn't stick my flashlight or my phone on it and be hands free. I tend to grab it in the middle of the night when the dogs want to go outside, too. Quick and easy, and everything I need in one area.