I have the S&W 22A, the Ruger 22/45 mkIII and the High Standard Duramatic 101. The Duramatic has the coolest vibe and is accurate. I mention this gun because it's one of the few old Jigh Standards that's safe to put HV ammo through. It's also reliable, but only with original High Standard mags, which aren't easy to come by.
The Ruger has the shortest barrel, and is comfortable to hold and carry. Fairly accurate and reliable...but you need to beware that some people have problems reassembling them. Some experts will say, "that's never happened to to me, so it must be a myth." But it isn't a myth. Many people have problems. Doesn't mean you will, and it doesn't mean the people who have trouble trying to put it back together aren't to blame...just means they have problems. Don't know about the regular mk series.
For the me, the winner of the best value award is the Smith and Wesson 22A. Not as pretty as the Ruger, but not as odd looking as the Berreta, either. Mine was a tack driver right out of the box, but there's a little nylon recoil buffer that has to be replaced now and then. Very reliable with most ammo I've tried.