Primers must have two things for reliable ignition reliability. They must have SPEED AND ENERGY. Remove one or reduce one and you will get misfires.
The allowable misfire rate on US primers by all manufacturers is 1 in a million.
Handguns are notorius for not having enough ignition energy and unless you have the gage fixtures and the equipment to measure striker indents your incidence of misfire will most likely occur and you not know why.
As well if the primer indent is off center over .020 the misfire rate should not be affected. Once you pass .020" offset the chances of misfires starts to rise. This is not measured by looking at overall indent but measuring from the dead center of the primer to the dead center of the firing pin indent.
Most vendors have an internal tolerance of 1/2 the diameter of the striker offset. Most small pistol strikers run about .060" diameter thusly their tolerance can allow a .030" offset.
Couple offset of indent with reduced striker energy or velocity and your misfire rate can go out the roof and it is all the fault of the design and not the primers. Just because one primer will go off and another won't doesn't mean it is not the gun, just has a more sensitive primer.
The hardest primer to ignite in the US inventory is the 50 BMG. Second is the 5.56 MILSPEC primers and the easiest to ignite is the small pistol primers on 38 special.
Finally all bets are off if you ammo has been exposed to water, oil, high temperature (car trunk, dash of pick up etc) Most commercial ammo is no longer waterproofed (the blue/red/green) sealant around the edge of primers.
Without this moisture out of the air can kill ammo.