If I had an unlimited budget this probably wouldn't be such a difficult decision for me.
To understand some of my questions, here is my final goal...
1) accurate to 200 yards (A 2-3 inch group would suffice. I'm not shooting competitions, I'm killing things and everything I intend to kill has a vital zone larger than 2-3 inches.)
2) Easily attainable ammo would be nice. (I don't currently reload. I save all my brass because one day I intend to get into it. But I like the convenience of being able to just grab a box of ammo off the shelf and go shoot.)
3) Needs to be able to kill at range. (I know even a .22lr can kill at range. I want a fairly quick kill. I don't want to track an animal all the way across the county and if the weapon is ever used in a self defense scenario I want it to end the fight with one shot.) This point brings up a question about the possibility of using a 45ACP...We know the 45ACP is very capable of quickly killing people. Is it at all effective against the 4-legged variety (coyotes, pigs, deer, etc...)?
Dude, if you really want to accomplish your goal, go back and read what I wrote on page 1, and then re-read it again, and ignore anything to the contrary, or you're shooting yourself in the foot.
Lookit, assuming an accurate gun, your ability to (a)
minimize wind drift estimation error, and (b)
minimize holdover estimation error, are entirely dependent on TWO things (in addition to your skill): Bullet velocity, and Bullet BC. In THIS particular case, with a subsonic bullet, ONE of those two factors, muzzle velocity, is a set constant, under the speed of sound, right around 1,050 fps. That means the ONLY thing you have to work with, above and beyond skill level, which will help improve your accuracy at range (and make no mistake, 200 yards is a loooong ways with a subsonic), is
BULLET BC. Particularly, wind drift estimation error.
The .500 phantom / .510 whisper uses bullet with BCs head and shoulders above (much much MUCH better) than any other subsonic round. That's the way to go if you're SERIOUS about it. However, .50 cal cans are very very expensive. 338 spectre is the next best thing, because you can use a simple 9mm pistol can with subsonic ammo, and get into it for a reasonable price. And .338 bullets have better BCs than .30 cal bullets, not to mention, more weight/energy/oomph. So .300 Whisper is not a BAD choice, but it's not as good of a choice as .338 spectre or .500 Phantom / .510 whisper. But 9x19mm, .45 acp ARE bad choices for this application (shooting accurate to 200 yards), due to the horrid BCs. Look at the links from my post on page 1 to get started, or PM me. .338 spectre is where it's at for me personally, as the best balance of performance and reasonable price to get into. Relative to a .50 cal can, a 9mm can is a mere pittance. But again, if budget is unlimited, you're not gonna beat the .500 Phantom / .510 whisper.
If your goal was to get a 5-10 inch group at 200, then .45 acp would be fine, but if you want to get under 4-5" groups realistically at 200 yards, then you've got to step up from a pistol caliber.
It should also be noted that you're talking about HUNTING with such a rig. Well, for hunting, you *definitely* want the higher sectional densities and weights of the calibers I mention: .300 whisper, .338 spectre, .500 phantom / .510 whisper.
So FORGET pistol calibers (unless you change your specifications).