Yes, that is good advice. I tend to shoot onehanded like I would in competition when testing loads, but I'll generally devote a range visit to a specific load. This is a much slower way of finding the ideal load.
As for the Pietta NMA liking hot load and ball, interesting. My Uberti NMA likes hot load plus conical much better then hot load with .457 ball, which is not very accurate. I imagine this is because of fairly fast rifling twist in modern built Uberti NMAs so a really fast round ball would get too much spin but a slow ball or fast conical would be ideal.
Last time I shot paper cartridges with 22gr of black and a Lee 200 gr conical, scored 83/100 by mlaic scoring with one bullet less. This kind of load is something quite close to authentic combustible paper cartridges of the civil war era, and it is definitely accurate enough for any practical purpose. It would be sufficient for a hunting sidearm, imo, but I don't have a chronograph on hand.