Yes, the parts are "basically compatible", as much as any two Blackhawks are. Cylinders often have to be "fitted" right to a given gun to get the headspace/cylinder gap/endshake issues set right.
Odds of a zero-problem "transplant" on Ruger SAs seem to be around 50/50ish.
Use elements of the "revolver checkout" to make sure you've got a clean fit PRIOR TO FIRING!
If not, a gunsmith can set it right and still have the original cylinder work.