I'd probably take the Model 19 of the choices you listed.
However, I'd take a Ruger SP-101 over any of those choices for an all around handgun. They are a little more packable for carry (not one of your current concerns, but you never know when it might become one) but still plenty shootable in the 3" version and SOLID. I loved my first so much I bought another! Admittedly, one is for sale now, but still those little guns have made an impression on me.
I also like the Ruger GP-100 better than the 686. I had a 686 once and while it was a good gun, I did shoot it enough to get it out of time. I've never accomplished that with any Ruger or even heard of it. I also shot another S&W out of time before and had the problem you describe on a third S&W with the cylinder being hard to open. It was the ejector rod unscrewing itself. Still, while I've liked the S&W's I've owned, I think Rugers are just a little more durable than S&W's in most respects.