Here's my two cents: I loved my SP-101, 2.25 but couldn't hit squat, so I sold it for some other purchase; then I bought a Taurus 817 which is a 7 shot 38, but the big brother to this is a 617 7 shot which I have not owned but it is the same size as the 817. The size is similar to a Smith K frame. The 617 weighs 27 ounces (I believe) and will cost about $475 from GB. The Taurus 817 that I mentioned, weighs only 19 ounces and has 7 shots of 38+P. If you decide that 38 +P is adequate, it's a winner. The 817 is harder to find then the 617.
I know there are a lot of naysayers for Taurus, but I've owned S&W's, Rugers and Taurus's and every Taurus that I've owned worked great plus they're guaranteed forever and the current customer service is not as bad as what you may hear. I currently carry a Taurus 856 which is a 6 shot 38+P. I put a Hogue grip on it to increase the grip size. This only weighs 21 ounces, is compact, costs around $375. The big brother to the 856 is the Taurus 605 5 shot 357. I know the argument that 5 shots should be enough for any conflict, but if you have a opportunity to bump it up to 6 or 7 shots, why not. That's why I looked to the 7 shot Taurus 817 38+P or the 617 357.
Having said all this, I owned a Speed Six, 2.75" that I loved but regretfully sold to once again buy something else. And then most recently, I bought a S&W 686+ 2.5" (7 shot) that I took to the range for the first time last night. I think this is my latest favorite. I told my son that I am going to give it to HIS 6 month old son when he makes Eagle Scout.