Bullet weight is #1, velocity is #2. Example #1. Remington single action replica. Factory 255 grain 45 Colt, 12" above poa at 2 5 yards. Sequentially, 250, 230, 225, 200, 185, and finally 155 grains bullets worked it down to poa=poi. We decided on 200 and I killed th rear slot slightly deeper. #2. TC Contender. 38 hbwc @795 was sighted dead on at 25. 357 158 jhp @1400 was 6" low. Mix to match. It can be done.