Ahhh...not sure,but...
I'm not sure what would happen with a Commander frame; follow:
Commander and OM frames and slides are drop on interchangeable. (Recon, CCO)
Colt Defender plus is Defender slide on OM frame, isn't it? At any rate, everything would work but the dust cover: would still be long, but no reason not fxl.
Colt put out a matched Gold cup set with a 5" and OM slide a few years back; dust cover was longer, but not more than OAL of OM slide. You did have to change the ejector though (Commander/OM ejector is narrower). I never did understand quite how that worked; GM rails are longer than Commander or OM rails by just a fraction.
Seems even more feasible with Kimbers, tho I have none here to try it with. Don't they do it on a production gun? or haven't they tried it?