I don't know anything about chemistry, but I have vacuum sealed stuff. When you put things that have hard parts and soft parts, the soft parts tend to get drawn out. Put in a steak, for instance, and all the liquids (blood) will start to be drawn out toward the suction pump.
I've been considering doing this for years but I've held off because I'm lazy and because I figured the primer might "flow" or "expand". Maybe some other weird or unexpected changes will occur. I don't know, but those of you with vacuum sealers should try sealing different things. Like a single Oreo cookie. (I haven't done it, but I'd imagine the cookies would try to get closer and the filling would start to squish out.)