Lots of good stuff above.
At one time I had the same ideas you are having now. Over the years, I came to the conclusion that loading several specialty loads for differing weapons is a logistics nightmare.
I currently load for 5 weapons chambered in .45 ACP. Three 1911 types, 5 inchers, an old 1917 S&W revolver, 5 1/2 inch barrel and a Marlin Campgun with a 16 1/2 inch barrel. Shooting the same loads, with a statistically valid number of samples, this is what I get:
45 L 204 231 5.6 867.2 1911 - HE
45 L 204 231 5.6 894.4 1911 - TT
45 L 204 231 5.6 869.0 1911 - TE
45 L 204 231 5.6 879.6 S&W 1917
45 L 204 231 5.6 1045.5 Marlin
These velocities samples were at 10 feet, on the same day. Yes, the lot of bullets did weigh in at 204 grains.
Now directly to your question. Yes, it would be possible to move to a different powder to make better use of the longer barrel. Further if you are only loading for that one weapon, that is what I would do. Load for the weapon. However, if you end up with what I will call 'plus P' loadings, be very careful not to let any slip into the hands of others. Back when I was a Deputy, I loaded up some, what I called 'barn burners' for a S&W Model 28. I kept them in my breif case until someone snached 6 from the box. My fear was what would happen if any of those were fired in a Model 19 or other 'K' frame or lesser revolver.
What ever you determine to do, load with care.