I've thought this one over a couple times.
As Art said, gots to know your lay outs.
Trying to punch through a unibody construction vehicle from the side to nail the engine? It's gonna do who knows what to the bullet, if it's lead then the bullet is likely to begin to delaminate/fragment upon entering the first layer of sheet metal and progressively get worse from there. If it's a true AP bullet, who knows what kind of deflections might take place as it penetrates unibody construction while trying to do battle with things like steering pumps, exhaust manifold, and then get to the block.
For a front wheel drive car, going through the front of the car putting a shot square through the radiator aught to do tons of damage. Radiator would have very little effect on the round and a transverse mounted engine has either heads or cylinder walls in line with the radiator behind that. Would love to see a Neon eat a 30-06AP round or nastier when fired from straight on...
Lots of variables....
Personally? If the car is stopped I'd favor putting two or three rounds from the most potent thing you gots access to right through the front wheels with the intent of disrupting the brake rotor and the brake caliper.
Just one or two holes through the rotor are going to cause VERY wonky things to happen as said ventilated rotor has the brakes applied to it, if it's a serious caliber just two well placed shots are likely to cause the rotor to fracture. Ever see what happens to the idiots in the police chases down in LA when their wheels stop working as wheels? Not to mention if the brakes are totally gone thanks to having bled out vital fluid, said driver will probably wreck the vehicle when they try to stop.
I've got a nasty little load I was gonna try on an engine some time back where I found an abandoned vehicle out in a field, low and behold by the time I returned a week or two later somebody had yanked the engine on that rig. It was an OLD in line 6 from some old truck that looked to be a good 50+ years old, it was nothing but a rolling chassis with old rusted inoperable engine.
What round would I have tested? My 300WinMag rounds using 163grn WWII AP projectiles loaded to what is likely 3100+ fps, same rounds after a bit of load development are defeating a 1 1/4 inch steel plate.
Chairborne ranger returns to his post... keep up the good hypotheticals gentlemen! Over and out...