I use Pyrodex "P" in all of my C&B revolvers. No ignition problems using standard caps so far.
I use the 30 gr. pellets with a "Wonder Wad", swaged ball, and cigarette papers to make combustable cartridges for the .44s, too. There is no place within 50 miles of my home where I can buy genuine black gunpowder, but I can get Pyrodex at the local Wally World.
FWIW, I've resorted to Pyrodex "R" in revolvers when I ran out of "P" with no problems.
Don't see how one could get into much trouble using a volumetric measure just changing granulations, unless 4F priming powder was used. The weight/volume ratio shouldn't change that much between 2F and 3F.