Everything I've ever read about 10mm says even good hollow points over penetrate and go all the way through human targets much of the time. If that's still true I wouldn't even consider carrying a 10mm with FMJ for defense against two legged predators.
The people that say "shot placement is everything" have never been in a gunfight armed with a handgun. If you think you're going to pull off a head shot or CNS hit by any means other than sheer luck against a moving target that's shooting back you are just plain delusional. In the real world you'll be damned lucky if 25% of the rounds fired hit the bad guy at all.
I'll take a big, heavy bullet that causes maximum mechanical damage to whatever it does hit over one that requires impossible shot placement to be effective.
