Yes, I have carried several full-sized autos concealed: 1911s, SIG P220, Browning High-Power, G22, and presently, SIG P229. Yes, the P229 is quite full-sized, if one gets out a ruler and measures. Its barrel/slide may be a bit stubby, but not by much.
I will warn, however, that a G22 is NOT easy to conceal. One gun writer called full-sized Glocks boxes of Wheaties, when it comes to concealment.
Of the full-sized autoloaders I carried concealed, the BHP was the easiest, then the 1911 and P220 were about the same, and still quite easy. The P229, being double-stack, was a bit more challenging. The G22 was the most difficult. Notably, a "baby" G27 was almost as difficult as the G22, and more difficult than the SIGs, BHP, and 1911s, because the outside rear corner of the Glocks' slides tended to print against my clothing, when I wore them in my preferred location, as close to the point of my hip as comfort allowed. I can hide grip length, I can hide barrel/slide length, and I can manage width/chunkiness pretty well, but the protruding rear portion of the slide, made worse by the need to enclose a striker mechanism, is the hardest for me to conceal, all else being equal.
I used to be able to tell which of my co-workers were carrying Glocks concealed, because of the "Glock bump" where the outside rear corner of the slide touched their cover garment. Now, Glocks have been joined by other pistols with protruding slides, and the bumps are no longer just Glocks. Some folks think I am not carrying, because my bobbed-hammer DAK P229 pistols don't make the "bump" that shows up so distinctly. Folks have even thought I was not carrying, when I was carrying TWO of the P229s.
FWIW, nothing hides my SIGs like a Milt Sparks VM2 or a Garrity In-Cognito, though I actually mostly use a Bulman FDS, which being OWB, requires a slightly more substantial cover garment.