You can.
However, I will wager that I could take new/novice shooters (male or female) and give each about an hour of instruction on a pump gun and the Glock...and with defensive ammo in each, in a timed/stress induced course of fire, the pump would be more likely to malfunction and/or suffer more malfunctions per X number of rounds fired. I think it would take a long time training, more than the vast majority of people will ever do, to even reach the break-even point.
Talk to anybody who has shot shotguns enough, or been around enough people doing so for time/score, and ask them how often they see short stroking. I would put that rate up against a semi auto pistol, such as a Glock 19, that is using good mags and good quality defensive ammo, any day.
But that is just me and my experience.
I had a pump shotgun as my HD gun for a long time, and until last year it was still my main HD gun, slotted ahead of my Glocks. You can't argue with the terminal performance/effectiveness of a 12 gauge vs 9mm pistol.
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I have a Mossberg 500 12 gauge and I have never short stroked it, I have never had any problems whatsoever feeding, firing or ejecting ever. Like they say you just have to pump it with authority. I guess you could short stroke it if you work it like a sissy though. You shoot someone one time with a 12 gauge loaded with 00buck and its game over. follow up shots with 00buck shouldn't be necessary unless you miss or have multiple attackers. follow up shots aren't hard for any half way experienced shooter. get the 12 gauge out and go shoot some clays.