My only experience with the GS was in the form of the 180gr 40 cal I used in my 10mm. Like Walkalong, back when they first came out I picked up 1K of them pretty cheap. I really liked the profile with the reduced diameter nose just in front of the shank where the ogive starts. They were loaded to around 1300fps and at 50yds they shot so well I really couldn't believe it. They topped my GD load accuracy by a full inch.
That said, I use that pistol for hog hunting when we would run the dogs. It is more than accurate enough for a had shot at 25yds or closer, and light enough not to be bothersome while chasing the dogs through the briers and brambles.
I got on a big hog and the first shot came at about 30' or so. I put one of the GS's right under his ear, which should have ended things then and there. Instead however, he growled, lunged at the dogs, and was off to the races. Another hundred yards or so down the river bank, and they bayed him up again. Same thing only a few feet closer. Second round impacted within about an inch of the first, and again we were off to the races with a now VERY mad hog. The third bay was finished by a 30-30 at almost point blank range. We found that both of the GS had hit the skull and simply splattered resulting in a nasty wound under the hide, but nothing remotely fatal.
Up until this point I had used the GD almost exclusively with no issues what so ever. The same shot had been taken quite a few times with them resulting in a hog that was DRN. After that little trip through the woods, I relegated the GS's to more or less paper weights. They "might" work better in other situations on other targets, but they will have to do so in somebody elses handgun, not mine.