As far as shooting 125 Ballistic Tip and 220gr. bullets well, a 1-8" twist Douglas barrel did some fine shooting with a 16.5" Remington 700 in .300 Whisper. The 125's were printing under an inch, and the 220's wouild do as good as I could load them (loading pistol charges and expecting subminute @100 yards is often claimed, but I personally don't see it too much). Too many variables with the burn/volume/velocity fluctuations. However, having subsonic and suppressed 220's packing more punch at 400 yards than a .45acp does at the muzzle is nothing to snear at.