We have a number of range guns: Henry H001Y, Ruger 10/22, S&W MP15-22, SIG Mosquito and a pair of Walther P22s. The whole family enjoys shooting them and a couple of bulk boxes of Remington Golden Bullets make for a fun day at the range. I don't get to shoot these very much; I am busy loading magazines.
However, at least a couple of the heavier weapons go along on every trip. We have two S&W J-frames (M60 and M637), two full-size 9mms (Beretta PX4 Storm F and FNP-9) and three .380s (Beretta 84FS Cheetah, Browning BDA .380 and Walther PK380). They will account for a couple hundred rounds.
Home defense? My wife keeps her Browning in her nightstand, what I am carrying depends on what I am wearing and a Beretta CX4 carbine with a 20-round magazine is by the work area in my office, which has a commanding view of both front and rear doors.