Well, I cannot comment on the compact - I don't have one. BUT, my regular carry is the USP45 full size, and I carry without any problems. It just took me a while to find a setup that works....
I have a 2 inch nylon belt (a 72" luggage strap from walmart, cut a bit short) that holds a holster and a double mag pouch. A pair of perry suspenders (the kind that hooks to the belt) holds the belt/gun/mags up (I have to wear the belt loose, because I'm not supposed to wear belts at all - I have kidney stone problems). That all gets put on while I'm in t-shirt and tidy-whities. Then shirt and pants (again with suspenders), shirt tucked in to conceal top of pistol. I have a reversable left/right hand holster, so the gun can go on right hip or just to the right of the small of my back. Works just as well with shorts and a loose pull over shirt...