There are a lot of good guns on the market meeting your criteria. Most of us will just give you our favorites, and here are my thoughts:
If you like the Taurus Milennium Pro series, look them over at the gunstore before ruling them out due to no rail. Taurus has put these out with both configurations on and off for a while (my PT 140 Milennium Pro does not have a rail, but at the time almost all of them on the market did have a rail). Look around and you may find one with a rail. My PT140 M. Pro (the older DAO version) is one of my best guns and I have a couple SIGs, a CZ, and several other high quality guns.
If the Milennium Pro won't work for you, the 24/7 is mostly a larger version and it does have a rail.
Depending upon why you sold the SIG you may want to reconsider another. I love my SIG 229 (.40) and 226 (9mm). A 220 or 220 Combat is definately on my wish list. They are good guns and if it is a trigger issue, they have several options (regular DA, regular DAO, DAK, the short trigger in DA, and they have a SA version out now as well).
If you like the 1911 design, the SIG version can be had with a rail.
A couple people have suggested the Ruger P345. I was in the market for a .45ACP for home defense just like you (I actually prefer .40 for CCW and general defensive use, but the combination of decent power, lower decibel levels than just about any caliber other than .38spl, lowish recoil for quick follow up shots, and lower overpenetration issues than .357mag, 9mm or .40 make the .45 tops in my book for HD). I ended up buying a Ruger KP345 for that purpose. It is the first Ruger auto that I can say actually looks good. Ergonomics were great- it just felt good in my hand. It may not be a 1911 trigger, but the trigger pull is actually pretty decent. To top it off, Ruger has a great reputation for reliability. So I bought one. Mine is a total piece of crap, it is truly the least reliable gun I've owned, and researching the net I see a lot of people have had trouble with theirs (a lot of people love theirs too, so consider that too). I've never been able to actually add mine to my roster of home defense guns, which is what I bought it for, and I'll sell it if I ever get it more than 75% reliable. Because of my experience I have trouble recommending the gun to others (though I'd love to be able to). I've replaced it with a S&W 1911SC (commander sized scandium 1911) which if it proves reliable (I haven't shot it yet) will be my home defense pistol and will probably compete with my Taurus PT140 Milennium Pro and SIG 229 as my primary carry pistols when I'm in VA or PA.
Other than those thoughts, there are a lot of good guns out there that will probably work for you. Just about any from HK, Glock, SA, Taurus (the PT 945 or the 24/7 are in .45), etc. will probably be a good gun. However, I limited my advice to guns I have experience with.