I agree with the OP in general terms. There are certain limited scopes of hunting where minutia become consequential...i.e. extreme range shooting of game. Its a topic for another debate which I care not to join, but in pushing a big game caliber/rifle to the absolute limit, every fraction of an MOA can make a difference.
Back to the general topic of shooting a deer, elk, moose, bear to 300 yards or so with a modern centerfire in the .243-30-06 ballpark with say a 3x9 quality optic. If you can shoot 2 MOA from a supported field position, and know how to roughly judge conditions such as wind and shot angle, or opt to pass shots involving such conditions, you're there. I personally don't waste a lot of time and components with load development once I crack the 2 MOA mark. I do shoot a relatively "flat" cartridge and bullet to hedge my bets on conditions at the limits of range. I also try to set up longer shooting scenarios with a field expedient rest, and practice accordingly.
Back before the internet knew better, I used to dump whitetails with a .308 bone stock R788 with a Swift 2x7 and Hornady 150 flat based spire points to 300 yards (my self imposed limit on healthy deer). 2 known wounded animals I took at 420 and 450 yards across prairie grass in Central WI over homemade shooting sticks of survey stakes and a bent nail. I rarely took the scope off 4x. Military ammo which shot near the POI of hunting loads was dirt cheap, and I had access to lots of open fields of public land with dirt piles on the far end. I did a lot of shooting from field positions in various conditions with that rifle, and knew it like an old lover. I also shot a lot of running/trotting deer with that rifle to 100 yards on drives, and a lot of snap shots in the woods, logging roads, or clearcuts from point blank to 200 yards. With a lot of practice, I was confident offhand to that distance, more so sitting or braced on a sapling if that was an option. Don't think my eyes, muscles, and overall skills are up to that anymore, so now my offhand range is shorter even with a superior rifle/scope/cartridge. Know your rifle, get it solid, and shoot deer.