How vigorous are your daily activities? You'll need to insure that any external controls on the gun, such as the safety (if there is one) and the magazine release, are not accidentally actuated. When I was on the job, holster selection for such carry was thin, and only what you could get locally. For those concerns, most cops I knew that carried a second gun carried a J-frame type. So did I, a Charter Arms Undercover that I still own. I had no issues keeping that gun secured, nor with my own balance, during the sometimes-rigorous duties of police work.
Now, with the incredible selection of guns available, it doesn't make much sense to exclude them all over concerns about the levers and buttons on them if you can be careful about holster selection (also much improved since back then.)
My current second gun, a P32, is pocket-carried. I wear jeans and boots virtually all the time when wearing anything. One pair of boots is cowboy-type, taller than the other. These make wearing an ankle gun more difficult. While I could wear a gun in the boot, I don't want to have to find a place for the gun if I take the boots off somewhere.
If I was going to wear an ankle gun now, and could only choose from the guns I currently own, it would probably be my Taurus TCP over the P32 because the Kel-Tec's magazine is too easily accidentally actuated (the release button sticks out more.) But, I do have an old Grendel P10 that would give me up to eleven rounds of .380, and has no safety or magazine release.
Another suggestion would be to carry the gun on your
strong-side leg so it can be accessible easily with either hand.