Colt used to advertise that their cylinders rotate "The RIGHT direction" (as opposed to the left, like S&W) and that this helped hold the crane tighter against the frame.
And Colt was correct -- which is why S&W had to have a second lock at the end of the ejector rod.
Oh gee, I was wondering how long it would take for that tired old argument to surface.
The very first Smith and Wesson 38 Hand Ejector, the Model 1899 did not have the underlug and locking latch at the front of the ejector rod. This one was made in 1902, the last year they made them. Despite the fact that the cylinder rotates in the 'wrong' direction, this one shoots just fine and there is no tendency for the cylinder to open as the hand pushes it around. So much for that argument.
Personally, I think S&W added the latch at the front because it was a better idea to protect the end of the ejector rod from being bumped or whacked, and possibly bent, than leaving it hanging in the air the way Colt did.
Yes, for what ever reason, Colts and Smiths were kind of 'mirror images'. The side plates came off on opposite sides, and the lockworks were laid in to accommodate the location of the side plate, with the hand or pawl, whatever you want to call it, just under the side plate.
The old S&W Top Breaks had the side plate on the left side of the gun, the hand pushed the cylinder around clockwise when viewed from the rear.
Same with the even older S&W Tip Ups. Side plate on the left, cylinder goes clockwise.
As previously stated, Colt (and Remington) Single Action revolvers were evolutionary advances of their older Percussion designs. It makes more sense to rotate the cylinder away from the barrel than towards it. A high cap rotating past the breech and the hammer would not be a good idea.