My Model 342 Ti-Lite left lingering pain in the base joint of my thumb, lasting 2+ weeks, as I recall. Being no dummy, I sold it, and kept my Airweight, which, though only a few ounces heavier, remained above the point of diminishing returns, leaving me with no lingering pain.
I am in the process of re-examining my carry weapons, and the feasibility of continuing my LE career, as the recoil of my duty SIG P229, in .40, is really scrambling the bones in my right wrist, so that I see the P229 as a torture device. (Keep in mind a P229 has a very hig bore axis, so the weapon applies more torque than a pistol with a lower bore axis.) I reckon
those big-bore magnums I fired in the 1980s are making themselves felt now; I wish I had never heard of the .44 Magnum, as it hurt back then, and is probably what is causing my problems now. Lesson: if it hurts long after the shooting session is over, stop doing it.
Having said that, make sure you are holding your weapon correctly, high on the grip. Holding too low on the grip causes more torque against the base of the thumb and the web of the hand. I sold my first SP101 because it hurt, but then realized I had been holding it too low. I bought another, and hold it high on the grip, so it does not hurt.